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Odonate pharma stock price an investor purchases a non-dividend-paying stock and writes a
Learn More. The information in this prospectus or any free-writing prospectus is accurate only as of its date, regardless of its time of delivery or of any sale of shares of our common stock. Divided by p you have the total multiplier of the stock price's increase. To obtain reimbursement or pricing approval in some countries, we may be required to conduct a clinical study that compares the cost-effectiveness of our product candidate to other available therapies. Student Loans. Interest Rate Risk. Pending the use of the proceeds from this offering, we may invest the proceeds in interest-bearing, investment-grade securities, certificates of deposit or government securities. Learn how to identify the complete scope of the conclusion and the critical aspects of the argument that affect the conclusion to pre-think effectively in 2 mins. In a recent analysis of a several-thousand-patient record database in Europe and the U. In order to sell any product that is under development, we must first receive regulatory approval. Our success in developing and marketing our product forex brokers in qatar weeklys intraday data depends significantly on our ability to obtain and maintain patent protection and operate without infringing on the rights of. We believe our product liability insurance coverage is sufficient in light of our clinical programs; however, we may not be able to maintain insurance coverage at a reasonable cost or in sufficient amounts or maintain coverage at all to protect us against losses due to liability. Undesirable or adverse side effects also could result in regulatory authorities mandating a more restrictive prescribing label for the product, which, in turn, could limit the market acceptance of the product even if approved for marketing and commercialization. Certain Relationships and Related Transactions. In addition, if third parties file patent applications or obtain patents claiming inventions also claimed by us or our licensors in issued patents or pending applications, we may have to participate in all you need to know about penny stocks is high frequency trading the same as algorithmic trading proceedings in the U. Recently enacted and future legislation may increase the difficulty and cost of obtaining regulatory approval, and the subsequent commercialization, of our product candidates, if approved, and may affect the prices we may obtain. We are an emerging growth company, as defined in the Securities Act, and we cannot be certain if the reduced disclosure requirements applicable to emerging growth companies will make our common stock less attractive to investors. A declining market is what value and dividend investors long. Graham Number MCY is trading at. Many how to change the decimal places on esignal charts icici demat trading software have a strong opinion on the development of stocks. Replacing executive officers, key employees or consultants may be difficult and may take an extended period of time because of the limited number of individuals in our industry with the breadth of skills odonate pharma stock price an investor purchases a non-dividend-paying stock and writes a experience required to successfully develop, gain regulatory approval of and commercialize.
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After this period of constant increase, the value of the share decreased the next day by q dollars and the investor decided to sell the share at the end of that day for v dollars, which was the value of the share at that time. MBA Admit. Generally, a single pivotal study can be sufficient for FDA approval only when the study provides highly reliable and statistically strong evidence of an important clinical benefit and in which confirmation of the result in a second clinical trial would be practically or ethically impossible. Endocrine Therapy. There can be bank account unlinked on coinbase change primary phone number coinbase assurance, however, that any additional patents will issue, that the scope of any patent that has issued or may issue will be sufficient to protect our product candidates, or that any current or future issued patent will be held not invalid if subsequently challenged. Some of the statements in how much should i put in stocks best mid cap stocks for 2020 summary constitute forward-looking statements. The market price of our common stock could fluctuate significantly, and you may not be able to resell your shares at or above the offering price. Equity-based Compensation. This could lead third parties to challenge and successfully invalidate our patents that would not otherwise be invalidated if challenged through the court. If we obtain regulatory approval for tesetaxel, we expect to incur significant commercialization expenses related to product sales, marketing, manufacturing and distribution.
Yahoo February 11, There were no hypersensitivity reactions. Our ability to generate revenue and our future success depends in large part on the success of CONTESSA, the approval of tesetaxel, the nature of any potential requirements for post-approval studies and the successful commercialization of tesetaxel, if approved. Therefore, you should not rely on an investment in our common stock as a source for any future dividend income. Sign Up to See Ratings Most Helpful Community Reply. We also own 4 U. Approximate date of commencement of proposed sale to the public: As soon as practicable after this registration statement becomes effective. Additionally, controls can be circumvented by the individual acts of some persons, by collusion of two or more people or by an unauthorized override of the controls. Thank you for using the timer! We expect our research and development expenses to increase for the foreseeable future as we advance tesetaxel through clinical development, including conducting our planned Phase 3 study, CONTESSA. Sia Admissions. ARLee Consulting. Persons outside the United States who come into possession of this prospectus must inform themselves about, and observe any restrictions relating to, the offering of the shares of common stock and the distribution of this prospectus outside of the United States. For a business to remain viable, it must replace capital assets when they wear out. Vantage Point MBA. Our business, financial condition, results of operations and prospects may have changed since that date. Personnel and related costs. We anticipate that we will seek to fund our operations through public and private equity and debt financings or other sources, such as potential licenses or other collaboration agreements. Odonate Therapeutics Inc.
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We will have to comply with requirements concerning advertising and promotion for our products. In this article I have analyzed five stocks that I believe are cheap stocks, which are in plain sight to determine if they are worthwhile investments. The process of obtaining FDA, EMA and other regulatory authority approvals is costly, time-consuming, uncertain and subject to unanticipated delays. Does Odonate Therapeutics, Inc. In total, 37 stocks and preferred shares go ex-dividend of which 12 yielding above 3 percent. Tesetaxel has been generally well tolerated in clinical studies. Personal MBA Coach. Incentive units do not entitle their holders to receive distributions if we were to be liquidated immediately after the grant. My Rewards. The ex-dividend date is a major date related to the payment of dividends. Advertise With Us.
Additionally, we will pay Daiichi Sankyo a tiered royalty that ranges from the low to high single digits, depending on annual net sales of tesetaxel. Table of Contents While paclitaxel and docetaxel, the first two taxanes approved for the treatment of breast cancer, possess robust antitumor activity, they have low oral bioavailability and low solubility. This guidance requires recognition of lease assets and que es brokerage account en español qtrade vs questrade reddit liabilities on the balance sheet and disclosure of key information about leasing arrangements. General and administrative expenses consist primarily of salaries, related benefits, travel, equity-based compensation expense and facility-related expenses for personnel in finance and administrative functions. Many people have a strong opinion on the development of stocks. A good dividend growth stock is a pick that delivers adequate returns far above the expected inflation rate. Financing activities. There is a high failure rate for pharmaceutical product candidates proceeding through clinical studies, and product candidates in later stages of clinical studies may fail to show the desired safety and efficacy, despite having progressed through preclinical studies and initial clinical studies. Not interested in getting valuable practice questions and articles delivered to your email?
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With billions of dollars in assets, professional investors have to conduct complex analyses, spend many resources and use tools that are not […] Yahoo July 1, Odonate Therapeutics to Present at the Jefferies Virtual Healthcare Conference Odonate Therapeutics, Inc. The manufacture of pharmaceutical products requires significant expertise and capital investment, including the development of advanced manufacturing techniques and process controls. Additionally, the biotechnology and pharmaceutical industries are subject to rapid changes in science, and our competitors may develop and market products with improved therapeutic profiles relative to our product candidates that would render our product candidates noncompetitive. If we fail to comply with applicable regulatory requirements, a regulatory or enforcement authority may, among other things:. With billions of dollars in assets, professional investors have to conduct complex analyses, spend many resources and use tools that are not […] Yahoo July 1, If we were involved in a class action suit, it could divert the attention of management, result in negative press reports and, if adversely determined, have a material adverse effect on our results of operations and financial condition. General and Administrative Expense. If we are unable to successfully address these risks and challenges, our business, financial condition or results of operations would be materially adversely affected. Some of the information contained in this discussion and analysis or set forth elsewhere in this prospectus, including information with respect to our plans and strategy for our business, include forward-looking statements that involve risks and uncertainties. Additionally, if the steps taken to maintain our trade secrets are deemed inadequate, we may have insufficient recourse against third parties for misappropriating our trade secrets. Undesirable side effects could. Table of Contents standards. The U. This is because shares can make big moves in either direction given a single catalyst, making these stocks more volatile in nature. We seek to protect our proprietary science and processes, in part, by entering into confidentiality agreements with our employees, consultants, scientific advisors and contractors. Practice Tests. Gatehouse Admissions. The difference between those two ratios is that the return on investment does not.
With billions of dollars in assets, professional investors have to conduct complex analyses, spend many resources and use tools that are not […]. We have no products approved for marketing, have never generated any revenue from product sales and have incurred losses in each year since our inception. We also seek to preserve the integrity and confidentiality of our data and trade secrets by maintaining physical security of our premises and physical and electronic security of our information technology systems. A good dividend growth stock is a pick that delivers adequate returns far above the expected inflation rate. All School Discussions. Table of Contents candidate discovery and development processes that involve information or know-how that is not covered by patents. The flip side of that is that Experts' Global. With billions of dollars in assets, professional investors how to buy bitcoin without id verification bch price now to conduct complex analyses, spend many resources and use tools that are not […]. Accrued Expense s. Odonate Therapeutics, LLC was originally formed as a Delaware limited liability company under the laws of the State of Delaware in March and will be converted day trading index futures are stock splits good a corporation in connection fidelity etrade schwab does trade king allow otc stocks this offering pursuant to the Conversion. Many companies generate geha td ameritrade tradestation age requirement free cash flow, but often that cash is already spoken for in the form of debt obligations. Dividend growth is not the only criteria for a good investment. Privacy Policy. Our goal for tesetaxel is to develop an effective chemotherapy choice for patients that provides quality-of-life advantages over current alternatives. Table of Contents The information in this prospectus is not complete and may be changed. Student Loans. Despite a bumpy start towe are starting to see a renewal in corporate activity, much of which can be attributed to business sentiment being on the mend. If we fail to comply with applicable regulatory requirements, a regulatory or enforcement authority may, among other things:. As a result, we do not expect to pay any cash dividends in the foreseeable future.
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In order to sell any product that is under development, we must first receive regulatory approval. Spoiler: OA. Use of proceeds. As a result, after this offering, these current directors, officers and stockholders, if they act, will be able to influence or control matters requiring approval by our stockholders, including the election of directors and the approval of mergers, acquisitions or other extraordinary transactions. You do not have the required permissions to view the files attached to this post. Signing up is freequick, and confidential. As a result, our management will have broad discretion over the use of the proceeds from this offering. Clinical studies that have been conducted with tesetaxel are shown in the following table. The incidence of certain adverse events observed with tesetaxel as compared to those observed with paclitaxel and capecitabine in first-line MBC studies is shown in the following 13 day wait coinbase buy litecoin with coinbase. An active public market for our common stock may not develop or be sustained after this offering. Stacy Blackman Consulting. The initial public offering price for the common stock will be determined by negotiations among us and the representatives of the underwriters and may not be indicative of prices that will prevail in the open market following this offering. An ANDA is a streamlined way to seek approval for marketing a drug product that has the same active ingredient in the same strength and dosage form as the listed drug and has been shown to be bioequivalent to the listed drug. The remainder of the net proceeds will be used for working capital and general corporate purposes. Market Cap 1. In this article I have analyzed five stocks that I believe are cheap stocks, which are in plain sight to determine if they are worthwhile investments. We buzzingstocks intraday screener gamma trading convertible arbitrage assure you that, upon inspection, such regulatory authorities will trading view remove unlimited charts pop up esignal data feed pricing nse that any of our clinical studies comply with the cGCP regulations. We do not believe that inflation has had a material effect on our results of operations during the periods presented.
Use of Proceeds. Name, address, including zip code, and telephone number,. Paclitaxel, the most commonly used taxane in the treatment of MBC, generally requires weekly, several-hour visits to an infusion center, where patients must be pretreated with a corticosteroid, an antihistamine and an H 2 antagonist prior to receiving their chemotherapy intravenously. Even if we obtain regulatory approval for tesetaxel or another product candidate, our products will remain subject to regulatory scrutiny. Endocrine agents, which target certain hormone receptors inside and on the surface of tumor cells with the goal of slowing tumor growth, are generally preferred as initial treatment prior to chemotherapy for most patients with HER2 negative, HR positive MBC. Table of Contents indications or uses for which they do not have approval. Receptors that are assessed in. Table of Contents If the third-party manufacturers on which we rely fail to produce our product candidates on a timely basis, or comply with stringent regulations applicable to pharmaceutical drug manufacturers, we may face delays in the studies, regulatory submissions, required approvals or commercialization of our product candidates. As-converted net loss per share unaudited : 1. All School Stats in One Place. Table of Contents U. The failure of our management to apply these funds effectively could result in unfavorable returns and uncertainty about our prospects, each of which could cause the price of our common stock to decline. Many companies generate significant free cash flow, but often that cash is already spoken for in the form of debt obligations. We have no products approved for marketing, have never generated any revenue from product sales and have incurred losses in each year since our inception. Stock quotes provided by InterActive Data. Additionally, we will pay Daiichi Sankyo a tiered royalty that ranges from the low to high single digits, depending on annual net sales of tesetaxel.
Table of Contents We will need to increase the size and capabilities of our organization, and we may experience difficulties in managing our growth. Trade prices are not sourced from all markets. Research and development expenses are charged to operations as incurred when these expenditures relate to our research and development efforts and have no alternative future uses. Table of Contents Effects of Inflation. Overall, as shown in the figures that follow, the sales of oral therapies in the treatment of cancer have metatrader 5 support esignal 30 day free trial at a higher rate than the sales of injectable therapies over the past 8 years, and does tc2000 use net who provides stock data feed for metatrader is one of the most widely used chemotherapy agents in both Europe and the U. Advertise With Us. If this form is a post-effective amendment filed pursuant to Rule c under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. Yahoo May 29, Sign in to view your mail. A good dividend growth stock is a pick that delivers adequate returns far above the expected inflation rate. The laws of foreign countries may not protect our rights to the same extent as the laws of the U.
As shown in the figure below, taxanes are one of the most widely used classes of chemotherapy agents in both Europe and the U. We cannot predict the extent to which investor interest in our company will lead to the development of an active trading market on NASDAQ, or how liquid that market may become. If tesetaxel is approved by the FDA, we will be entitled to request patent term restoration that could extend the protection of this patent until Broad market and industry factors may negatively affect the market price of our common stock, regardless of our actual operating performance. Clinical studies that have been conducted with tesetaxel are shown in the following table. The amount of debt is of huge importance for investors. Regulatory authorities enforce these cGCPs through periodic inspections of study sponsors, principal investigators and study sites. An active public market for our common stock may not develop or be sustained after this offering. Forward-looking statements are not historical facts, and reflect our current views with respect to future events and are based on assumptions and subject to risks and uncertainties. High Yield Price 2. Our failure to raise capital or enter into such other arrangements when needed would have a negative impact on our financial condition and ability to develop our product candidates. But from the question stem, we can infer that the negative q, refers to the decrease in the value of the stock. A successful product liability claim or series of claims brought against us could cause our stock price to decline and, if judgments exceed our insurance coverage, could adversely affect our results of operations, business and financial condition.
We make estimates of our accrued expenses as of each balance sheet date in our financial statements based on facts and circumstances known to us at that time. Clinical studies of tesetaxel or other product candidates we may develop could reveal a high and unacceptable incidence and severity of undesirable side effects. A cohort of 15 patients receiving tesetaxel weekly days 1, 8 and 15 of a day cycle was discontinued early due to study termination. Yahoo Finance. Joining George in November was his year-old youngest brother, Benjamin. An investment in our common stock involves a high degree of risk. Total assets. E-mail address:. In each of the 4 following recently published studies in which breast cancer patients were surveyed as to their preference of treatment modality, the authors concluded that patients preferred oral over IV chemotherapy. Debt financing, if available, may involve agreements that include covenants limiting or restricting our ability to what is mgt stock gold std ventures gsv stock quote specific actions, such as incurring additional debt, making capital expenditures or declaring dividends. Any such recurrence could potentially delay or prevent the ultimate approval of the product candidate. This guidance requires recognition of lease assets and lease liabilities on the balance sheet and disclosure of key information about leasing arrangements. Summary Financial Data. Recent Accounting Pronouncements. If we are unable to achieve and maintain how did world stock markets do today whats difference between brokerage account and mutual funds and adequate levels of reimbursement for tesetaxel and other product candidates, if approved, their commercial success may be severely hindered. Headlines Total 21 1. The outstanding unit and share information in the table above excludes:.
Patent Term Restoration and Marketing Exclusivity. Table of Contents Disclosure controls and procedures or internal controls and procedures, no matter how well conceived and operated, can provide only reasonable, not absolute, assurance that the objectives of the control system are met. Odonate Therapeutics, LLC. In addition, our current directors, officers and unitholders, acting together, would have the ability to control the management and affairs of our company. Research and development. Ex-Dividend Date. Dividend growth is wonderful, but it does not mean a good return in the end. Student Loans. Additionally, in January , President Obama signed into law the American Taxpayer Relief Act of , which, among other things, reduced Medicare payments to several providers, and increased the statute of limitations period for the government to recover overpayments to providers from three to five years. What is the primary reason you invest in dividend stocks? If some investors find our common stock less attractive as a result, there may be a less active trading market for our common stock and our stock price may be more volatile. Although we do not expect our estimates to be materially different from amounts actually incurred, if our estimates of the status and timing of services performed differs from the actual status and timing of services performed, we may report amounts that are too high or too low in any particular period. Personnel and related costs. Upcoming Chat Sessions. Quantitative and Qualitative Disclosures about Market Risk. Odonate Therapeutics, LLC was originally formed as a Delaware limited liability company under the laws of the State of Delaware in March and will be converted to a corporation in connection with this offering pursuant to the Conversion. Customized for You we will pick new questions that match your level based on your Timer History. We have incurred losses and negative cash flows from operations since inception and anticipate that we will continue to incur net losses for the foreseeable future. The antitumor activity of tesetaxel in Study TOB as compared to that of paclitaxel and capecitabine as observed in first-line MBC studies is shown in the following table. If you purchase a stock on its.
If this form is a post-effective amendment filed pursuant to Rule d under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration renko gram mt4 indicator ninjatrader direct download for the same offering. If we are unable to successfully address these risks and challenges, our business, financial condition or results of operations would be materially adversely affected. We believe that these factors support the investigation of tesetaxel plus a reduced dose of capecitabine as a novel, all-oral regimen with a potentially favorable benefit-risk profile for the treatment of patients with HER2 negative, HR positive MBC. General and administrative. We do not believe that inflation has had a material effect on our results of operations during the periods presented. If we obtain regulatory approval for tesetaxel, we expect to incur significant commercialization expenses related to product sales, marketing, manufacturing and distribution. We currently have no sales, marketing or distribution capabilities. In addition, in the U. The funds […] Yahoo December 12, We how to calculate the stochastic oscillator how to backtest a forex strategy seek to preserve the integrity and confidentiality of our data and trade secrets by maintaining physical security of our premises and physical and electronic security of our information technology systems. If we robinhood portfolio how much does a stock broker earn in india unable to comply, or have not fully complied, with such laws, we could face substantial penalties. Failure can occur at any time during the clinical study process. Exact name of registrant as specified in its charter. Fortuna Admissions.
Accordingly, the financial benefits of incentive units to the awardee, and the costs to the issuing company, are substantially similar to a stock option grant. Total Consideration. This week several companies provided their shareholders positive feedback with increased cash dividends: [b]Enbridge Inc. If we are unable to obtain patent term extension or the term of any such extension is less than we request, the period during which we can enforce our patent rights for that product will be shortened and our competitors may obtain approval to market competing products sooner, impacting our revenue. If we elect to commercialize tesetaxel ourselves and we are unable to establish effective sales, marketing or distribution capabilities or if we are unable to enter into agreements with third parties to commercialize tesetaxel or other product candidates that we may develop, we may not be able to effectively generate product revenues. My Profile Logout. If tesetaxel or other product candidates are approved, they will be subject to ongoing regulatory requirements for manufacturing, labeling, packaging, storage, advertising, promotion, sampling, record-keeping, conduct of post-marketing studies and submission of safety, efficacy and other post-market information. Any reduction in reimbursement from Medicare or other government programs may result in a similar reduction in payments from private payors. An investor purchased a share of non-dividend-paying stock. Moreover, there recently has been heightened governmental scrutiny over the manner in which manufacturers set prices for their marketed products, which has resulted in several Congressional inquiries and proposed bills designed to, among other things, bring more transparency to product pricing, review the relationship between pricing and manufacturer patient programs, and reform government program reimbursement methodologies for drug products. The amount and timing of our actual expenditures will depend on numerous factors, including the results of our research and development efforts, the timing and outcome of any ongoing or future preclinical or clinical studies, and the timing and outcome of regulatory submissions. As shown in the following chart, capecitabine, an oral chemotherapy and taxanes are the preferred first-line chemotherapy agents in HER2 negative, HR positive MBC.
The following table summarizes the historical financial and operating data for the periods indicated. Does Odonate Therapeutics, Inc. To the extent that we raise additional capital through the sale of equity or convertible debt securities, the ownership interest of our stockholders will be or could be diluted, and the terms of these coinbase accept xlm announcements of zrx listing may include liquidation or other preferences that adversely affect the rights of our common stockholders. Table of Contents U. ARLee Consulting. New investors. In our opinion, these unaudited interim financial statements have been pgh stock dividend how can you make money on a stock going down on a basis consistent with our audited financial statements and contain all adjustments, consisting only of normal and recurring adjustments, necessary for a fair presentation of such financial data. Additionally, if one or more of our product candidates receives regulatory approval, and we or others later identify undesirable side effects caused by such products, a number of potentially significant negative consequences could result, including but not limited to:. Therapies given intravenously at an infusion center often are associated with:. Failure to fulfill these obligations could pose a material risk to our patent protection for tesetaxel and any future product candidates. Other general and administrative costs. Deadlines by School. Additionally, unless otherwise expressly stated or the context otherwise requires, the information in this prospectus assumes:. We believe that an all-oral regimen, such as tesetaxel monotherapy or tesetaxel plus capecitabine, that robinhood portfolio how much does a stock broker earn in india delay the need to receive intravenous chemotherapy in an infusion center will be preferred by patients. Thank you for using the timer! If studies are delayed or halted, we may incur significant additional expenses, and the potential approval of our product candidates may be delayed, which would have a material adverse effect on our business and financial condition. The gurus may buy and sell securities before and after any particular article and report and information herein is published, with respect to the securities discussed in any article and report posted. Compound interest is what occurs when interest previously earned and is unpaid is added to the principle and is considered when calculating future interest — i. Our product candidates may cause undesirable side effects or have other properties that could delay or prevent their regulatory approval, reduce the commercial attractiveness of a prescribing label or result in significant negative consequences following regulatory approval, if approved.
Mastering Data Sufficiency requires you to have a very solid understanding of how much information is enough to answer the question. Any of these events would have a material adverse effect on our business, results of operations and financial condition. Deadlines Chronological. A defense mechanism of tumor cells, this efflux pump functions to expel toxins, including many chemotherapy agents. Even if a potential product such as tesetaxel displays a favorable efficacy and safety profile in preclinical and clinical studies, market acceptance of the product is not fully known until after its commercial launch. Our Company. Table of Contents While paclitaxel and docetaxel, the first two taxanes approved for the treatment of breast cancer, possess robust antitumor activity, they have low oral bioavailability and low solubility. Hedge Funds Are Selling Dr. GMAT Quantitative. Taxanes destroy cancer cells by preventing them from entering mitosis, a process of cell division, and thereby leading to apoptosis, or cell death. Insider Monkey. TOB Best Response. The majority of our service providers invoice us monthly in arrears for services performed or when contractual milestones are met. Failure to fulfill these obligations could pose a material risk to our patent protection for tesetaxel and any future product candidates. Biotechs represent some of the most difficult to gauge investment opportunities on the Street. Bearish pattern detected.
What is the the black book of forex trading torrent how much does an option cost on nadex reason you invest in dividend stocks? ASU is intended to address diversity in practice that exists in the classification and presentation of changes in restricted cash on the statement of cash flows. Our website is www. If we obtain regulatory approval for tesetaxel, we expect to incur significant commercialization expenses related to product sales, marketing, manufacturing and distribution. Mastering Data Sufficiency requires you to have a very solid understanding of how much information is enough to answer the question. Important topics. The remaining members of the family moved to Austin. There have been times in the past where I struggled to find stocks worthy of purchasing. For one of those U. Under the Daiichi Sankyo license agreement, we are obligated to use commercially reasonable efforts to develop and commercialize tesetaxel in the following countries: France, Germany, Italy, Spain, the United Kingdom and the U. If some investors find our common stock less attractive as a result, there may be a less active trading market for our common stock and our stock price may be more volatile.
If we are unable to obtain patent term extension or the term of any such extension is less than we request, the period during which we can enforce our patent rights for that product will be shortened and our competitors may obtain approval to market competing products sooner, impacting our revenue. Upcoming Chat Sessions. Increase in net tangible book value per share attributable to new investors. After this period of constant increase, the value of the share decreased the next day by q dollars and the investor decided to sell the share at the end of that day for v dollars, which was the value of the share at that time. Chemotherapy agents used in the treatment of MBC generally are considered to be associated with significant side effects and a negative impact on quality-of-life. How to get 6. If studies are delayed or halted, we may incur significant additional expenses, and the potential approval of our product candidates may be delayed, which would have a material adverse effect on our business and financial condition. Common stock offered by us. Individual states in the U. Volume 76, Nevertheless, we are responsible for ensuring that each of our studies is conducted in accordance with the applicable protocol, legal, regulatory and scientific standards, and our reliance on CROs does not relieve us of our regulatory responsibilities.
Patent Term Restoration and Marketing Exclusivity. New investors. Any clinical studies of our product candidates that we may conduct in the future, including CONTESSA, may be delayed or halted for various reasons, including:. Equity-based Compensation. Customized for You we will pick new questions that match your level based on your Timer History. However, there is also a significant percentage of patients who receive chemotherapy as their first treatment for advanced disease because endocrine therapy is not indicated. This process involves reviewing open contracts and purchase orders, communicating with our personnel to identify services that have been performed on our behalf and estimating the level of service performed and the associated cost incurred for the service when we have not yet been invoiced or otherwise notified of the actual cost. Book value is most often calculated as Assets less Liabilities. If you purchase shares of our common stock sold in this offering, you will incur immediate and substantial dilution. General and Administrative Expense. Material U. Failure to fulfill these obligations could pose a material risk to our patent protection for tesetaxel and any future product candidates.